Nephron 1983;34:196-7. Clin Infect Dis 2000;31:1202-8.. View abstract. BMJ 1985;290:603-4. Fairbrother, K. J., Kowolik, M. J., Curzon, M. E., Muller, I., McKeown, S., Hill, C. M., Hannigan, C., Bartizek, R. D., and White, D. J. View abstract. As such, more research is needed to learn more about the connection between this mineral and eye health. Am J Clin Nutr 1981;34:1479-83. View abstract. View abstract. The University of Dhaka, Dhaka, Bangladesh. View abstract. Int.J.Radiat.Oncol.Biol.Phys. Recovery following peripheral destruction of olfactory neurons in young and adult mice. Wood RJ, Zheng JJ. Within my practice, common artificial sweetener side effects include diarrhea, abdominal pain, joint pain, cramping, a burning sensation while urinating, constipation, and headaches. Many factors can interfere with zinc absorption such as phytates in your brain and fibers. The elemental amount is usually listed on the label of your supplement, making it easy to determine how much to take to meet your daily needs. Demetree, J. W., Safer, L. F., and Artis, W. M. The effect of zinc on the sebum secretion rate. 2016;29(13):2194-8. Micronutrient supplementation in the AIDS diarrhea-wasting syndrome in Zambia: a randomized controlled trial. Drug Facts and Comparisons. View abstract. Valberg LS, Flanagan PR, Chamberlain MJ. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Attia JR, Holliday E, Weaver N, et al. Zinc in the human prostate gland: normal, hyperplastic and cancerous. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Growth and development in premature infants. 2013 Oct;98(4):960-71. J Nutr 1987;117:217-9. The effects of thiazides on serum and urinary zinc in patients with renal calculi. Effect of a chelating drug on balance and tissue distribution of four essential metals. View abstract. Akram M, Sullivan C, Mack G, Buchannan N. What is the clinical significance of reduced manganese and zinc levels in treated epileptic patients? View abstract. Different zinc supplements contain varying concentrations of elemental zinc. Walker, C. L. and Black, R. E. Zinc for the treatment of diarrhoea: effect on diarrhoea morbidity, mortality and incidence of future episodes. Marchesini, G., Bugianesi, E., Ronchi, M., Flamia, R., Thomaseth, K., and Pacini, G. Zinc supplementation improves glucose disposal in patients with cirrhosis. Bioavailability of orally administered zinc, using Taurizine. (Copenh) 1984;62(5):739-745. View abstract. Staub E, Evers K, Askie LM. Tremellen, K., Miari, G., Froiland, D., and Thompson, J. View abstract. Wong WY, Merkus HM, Thomas CM, et al. Joo YS, Kim HW, Lee S, et al. View abstract. View abstract. Med Hypotheses 1993;40:182-5. Clin Trials J 1990;27:301-312. View abstract. Cadmium in zinc-containing mineral supplements. DeCook CA, Hirsch AR. J Health Popul.Nutr. Clin Nutr. View abstract. zero sugars availability in many forms Stevia cons Some potential disadvantages to using stevia sweeteners include: Side effects. View abstract. Higher doses of supplemental zinc may be used to treat conditions like acne, diarrhea, and respiratory infections. Am J Clin Nutr 2002;75:181-2. 2013;30(4):593-9. Carducci B, Keats EC, Bhutta ZA. Indian J Physiol Pharmacol. 1991;28(1):11-19. Academic Press, New York, 1976. pp51-65. If you are not much into meats or seafood, other good sources include beans, whole grains, dairy products, cereals and nuts. Belmont, CA: Wadsworth, 1998. Effect of the administration of zinc sulfate on hypogonadism and impotence in patients with chronic stable hepatic cirrhosis. Eating lots of sugar alcohols can lead to bloating and an upset stomach. New treatment for faecal incontinence using zinc-aluminium ointment: a double-blind randomized trial. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Webb JL. Sian L, Krebs NF, Westcott JE, et al. Benso L, Gambotto S, Pastorin L, et al. Swe KM, Abas AB, Bhardwaj A, Barua A, Nair NS. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Effects of zinc supplementation on the immune system and on antibody response to multivalent influenza vaccine in hemodialysis patients. Ghorbani A, Akbari J, Boorboor M, Nekoukar Z, Eslami G. Evaluation of zinc sulfate mucoadhesive formulation on recurrent aphthous stomatitis: a randomized double-blind, placebo-controlled clinical trial. View abstract. Fosmire GJ. Adv Nutr. View abstract. Stomach ulcers. Bobat, R., Coovadia, H., Stephen, C., Naidoo, K. L., McKerrow, N., Black, R. E., and Moss, W. J. View abstract. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life. View abstract. Am J Clin Nutr 1979;32(3):559-569. Mei, W., Dong, Z. M., Liao, B. L., and Xu, H. B. Clin.Exp.Dermatol. View abstract. Crit Rev Food Sci Nutr 1995;35:495-508. Trace Elements in Human Health and Disease. A devoted follower of natural health, Susan had decided to stimulate her immune system with zinc. Taking zinc by mouth doesn't seem to help with hair loss. Best zero calorie sweetener. Altunbasak S, Biatmakoui F, Baytok V, et al. Zinc deficiency during captopril treatment. Ear Nose Throat J 2000;79:778-82.. View abstract. Palm R, Hallmans G. Zinc and copper metabolism in phenytoin therapy. Gibson RS, Yeudall F, Drost N, et al. Dhingra U, Kisenge R, Sudfeld CR, et al. View abstract. Howie S, Bottomley C, Chimah O, et al. View abstract. Zinc gluconate lozenges for common cold. When choosing a zinc supplement, youll likely notice that there are many different types available. Effects of diethyldithiocarbamate and tetrathylthiuram disulfide on zinc metabolism in mice. View abstract. Nutritional effects of oral zinc supplementation in cirrhosis. View abstract. 2013 Dec 15;74(12):872-8. Grattan, B. J. and Freake, H. C. Zinc and cancer: implications for LIV-1 in breast cancer. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. View abstract. View abstract. Zinc can decrease the amount of tetracyclines the body absorbs. View abstract. Frommer DJ. Br J Nutr 2003;89:695-703.. View abstract. View abstract. View abstract. Ophthalmology 1999;106:761-77. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Zinc side effects can become potentially serious if you take doses from 150 to 450 mg a day. Taking zinc sulfate by mouth also appears to help. View abstract. View abstract. View abstract. View abstract. In particular, the significant effect on blood glucose makes sucralose the worse option than stevia when losing weight. Broun ER, Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. View abstract. Zinc is an essential nutrient found in foods such as red meat, poultry, and fish. Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Zinc balance in adolescent females. Therapeutic Research Faculty 2020. Community Dent.Oral Epidemiol. View abstract. View abstract. Castro-Marrero J, Zaragoz MC, Lpez-Vlchez I, et al. But people who take lower levels of zinc can also experience zinc toxicity and zinc supplement side effects. Zinc is a very important mineral but you only need to take just enough. Dreno, B., Moyse, D., Alirezai, M., Amblard, P., Auffret, N., Beylot, C., Bodokh, I., Chivot, M., Daniel, F., Humbert, P., Meynadier, J., and Poli, F. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. Warts. Healthline Media does not provide medical advice, diagnosis, or treatment. Bullous lesions in acrodermatitis enteropathica. Am.J.Clin.Nutr. Effect of oral folic acid supplements on zinc, copper, and iron absorption and excretion. View abstract. Zinc decreases how much atazanavir the body absorbs. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Am J Clin Nutr 2002;75:99-103. O'Brien KO, Zavaleta N, Caulfield LE, et al. View abstract. View abstract. View abstract. Last updated on Sep 6, 2022. View abstract. Am J Clin Nutr 1998;68:484s-7s. Effect of zinc therapy on neutrophil chemotaxis in psoriasis. 2013 Dec;98(6):1468-74. A randomized, double-blind, placebo-controlled trial. Kauwell GPA, Baily LB, Gregory JF, et al. Clin Nutr 2022;41(5):1083-92. Penny ME, Peerson JM, Marin RM, et al. View abstract. The safety of sucralose at high . Arcasoy, A., Cavdar, A., Cin, S., Erten, J., Babacan, E., Gozdasoglu, S., and Akar, N. Effects of zinc supplementation on linear growth in beta-thalassemia (a new approach). Zinc lozenges reduce the duration of common cold symptoms. Contrib.Nephrol. Goldiner WH, Hamilton BP, Hyman PD, Russell RM. View abstract. Clin Toxicol (Phila) 2006;44:135-41. Rittenhouse T. The management of lower-extremity ulcers with zinc-saline wet dressings versus normal saline wet dressings. Sachdev, H. P., Mittal, N. K., and Yadav, H. S. Oral zinc supplementation in persistent diarrhoea in infants. View abstract. Ahmadi H, Mazloumi-Kiapey SS, Sadeghi O, et al. View abstract. Am J Clin Nutr. Von Hoff DD. Hansten PD, Horn JR. Drug Interactions Analysis and Management. You may report side effects to the FDA at 1-800-332-1088. 5 out of 5 stars review. View abstract. Higgins TL, Murray M, Kett DH, et al. Hunt CD, Johnson PE, Herbel J, Mullen LK. View abstract. Available at: https://hc-sc.gc.ca/dhp-mps/alt_formats/pdf/medeff/advisories-avis/prof/2010/poligrip_hpc-cps-eng.pdf. Int Urol Nephrol 1999;31:401-8. Epilepsia 1992;33:555-7. Vol 1, zinc and copper. Zinc concentration in plasma and erythrocytes of subjects receiving folic acid supplementation. Talebi S, Miraghajani M, Ghavami A, Mohammadi H. The effect of zinc supplementation in children with attention deficit hyperactivity disorder: A systematic review and dose-response meta-analysis of randomized clinical trials. Urol Res 1984;12:213-5. J Obstet Gynaecol Res. Interventions for managing taste disturbances. Acta Med Scand. Intorre, F., Polito, A., Andriollo-Sanchez, M., Azzini, E., Raguzzini, A., Toti, E., Zaccaria, M., Catasta, G., Meunier, N., Ducros, V., O'Connor, J. M., Coudray, C., Roussel, A. M., and Maiani, G. Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study. High dietary calcium intakes reduce zinc absorption and balance in humans. GlaxoSmithKline Consumer Advisory. View abstract. Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium, or zinc from food in humans. Sturman N, Deckx L, van Driel ML. Dutta, P., Mitra, U., Dutta, S., Naik, T. N., Rajendran, K., and Chatterjee, M. K. Zinc, vitamin A, and micronutrient supplementation in children with diarrhea: a randomized controlled clinical trial of combination therapy versus monotherapy. Available at: www.nap.edu/books/0309072794/html/. A., Bhandari, N., Teka, T., Shahid, F., Taneja, S., and Black, R. E. Zinc during and in convalescence from diarrhea has no demonstrable effect on subsequent morbidity and anthropometric status among infants <6 mo of age. View abstract. View abstract. In one case, a woman who took 400 mg of zinc a day became almost totally depleted of copper; her copper levels fell to 7 micrograms/dl, compared to an average of 70 to 155 micrograms/dl. Zetin, M. and Stone, R. A. Chew EY, Clemons TE, Agrn E, Sperduto RD, Sangiovanni JP, Kurinij N, Davis MD; Age-Related Eye Disease Study Research Group. A 2015 study found that high levels of aspartame may cause other changes in the body, such as changes in serum and oxidative stress markers, and can lead to type 2 diabetes . J Am Coll Nutr 1983;2:157-62. J Nutr Biochem. A double-blind clinical trial. View abstract. Stephen KW, Saxton CA, Jones CL, et al. Hustead, V. A., Greger, J. L., and Gutcher, G. R. Zinc supplementation and plasma concentration of vitamin A in preterm infants. Fortes C, Forastiere F, Agabiti N, et al. View abstract. View abstract. Pediatrics 2008;121(2):326-336. View abstract. Fischer Walker, C. L., Bhutta, Z. Jafek BW, Linschoten M, Murrow BW. Am J Clin Nutr 2008;88(1):154-160. BMJ Paediatr Open. Morgan, A. Najafabadi MM, Faghihi G, Emami A, Monghad M, Moeenzadeh F, Sharif N, Davarpanah Jazi AH. Arch Dermatol 1977;113:31-6. Sayyah M, Olapour A, Saeedabad Ys, Yazdan Parast R, Malayeri A. Voorhees, J. J., Chakrabarti, S. G., Botero, F., Miedler, L., and Harrell, E. R. Zinc therapy and distribution in psoriasis. Am J Clin Nutr 2002;76(6):1401-1408. Clin Infect Dis 2001;33:1865-70. Mostafa WZ, al-Zayer AA. View abstract. Other research shows that zinc may help reduce insulin resistance, which can improve your bodys ability to use insulin efficiently to maintain normal blood sugar levels (13, 14). 2013 Jul 18;122(3):311. Exp Clin Endocrinol Diabetes. Rambod M, Pasyar N, Ramzi M. The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy. 2010;5(4):e10386. Hormone Metab Res 1985;17:532-5. Taking zinc by mouth during pregnancy does not appear to reduce the risk of transmitting HIV to the infant or prevent other complications. Newsome DA, Swartz M, Leone NC, et al. J Nutr 2000;130:1378s-83s. 1986;9(2-3):241-252. View abstract. Nutr Res 2002;22:527-38. View abstract. View abstract. Li P, Xu J, Shi Y, Ye Y, Chen K, Yang J, Wu Y. Am J Clin Nutr 1993;57:673-8. Lancet 11-26-2005;366(9500):1862-1867. 2020;20(1):212. Am J Clin Nutr 1987;46:835-9. Am J Clin Nutr 2007;85(5):1293-1300. 1. View abstract. Yousefi A, Khani Khoozani Z, Zakerzadeh Forooshani S, Omrani N, Moini AM, Eskandari Y. View abstract. Lovell MA, Xie C, Markesbery WR. Clin Neurol Neurosurg. View abstract. While there has been limited research into gastrointestinal symptoms, artificial sweeteners have been linked to migraines in several clinical cases. View abstract. J Dermatolog.Treat. View abstract. Rahman MM, Wahed MA, Fuchs GJ, et al. 2020;4(1):e000662. View abstract. Stevia can cause gastrointestinal side effects in some. Eby GA. Zinc ion availability--the determinant of efficacy in zinc lozenge treatment of common colds. Zinc supplement use and risk of prostate cancer. View abstract. View abstract. Pharmacol Toxicol 1989;65:209-13. Bianchi GP, Marchesini G, Brizi M, et al. Cochrane Database Syst Rev. Cancer Chemother Pharmacol 1992;29:219-26. Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects. Reduced ability to taste (hypogeusia). JAMA 1990;264:1441-3. 1985;24(3):188-190. Silliman CC, Peterson VM, Mellman DL, et al. Mares-Perlman JA, Klein R, Klein BE, et al. J Neurol Sci 1998;158:47-52. 2012 Mar;30(1):22-6. View abstract. Peripheral olfactory deafferentation of the primary olfactory system in rats using ZnSO4 nasal spray with special reference to maternal behavior. Wester PO. Tang X, Shay NF. View abstract. Supplementing with 1530 mg of elemental zinc daily may improve immunity, blood sugar levels, and eye, heart, and skin health. Dimitropoulou, P., Nayee, S., Liu, J. F., Demetriou, L., van, Tongeren M., Hepworth, S. J., and Muir, K. R. Dietary zinc intake and brain cancer in adults: a case-control study. View abstract. Gynecol Obstet Invest 1988;25:113-7. Oral zinc as an adjunct to dapsone in lepromatous leprosy. View abstract. The results of a 2017 randomized trial suggest artificial sweeteners may increase BMI, weight, metabolic syndrome and type 2 diabetes, although more information is needed to be conclusive. Zinc supplementation in children and adolescents with acute leukemia. Stevia in the Raw was introduced to the sweetener market several decades ago as a low-calorie alternative to traditional processed sugar. Burd GD. 1988;32(1):47-50. Leary WP, Reyes AJ, Van der Byl K. Urinary magnesium and zinc excretion after two different single doses of amiloride in healthy adults. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. 2013 Jun;24(6):1175-83. Lawson KA, Wright ME, Subar A, et al. J Pediatr. View abstract. Oysters are the most excellent zinc sources. Age-Related Macular Degeneration PPP - Updated 2015. www.aao.org/preferred-practice-pattern/age-related-macular-degeneration-ppp-2015. Zinc supplements are often used to promote skin health and treat common skin conditions like acne (15). Nutr J. Pediatr.Pulmonol. Folic acid: effect on zinc absorption in humans and in the rat. Dan Med Bull 1986;33:208-11. Prostate cancer. Lessons learned from attempts to establish the blind in placebo-controlled trials of zinc for the common cold. Int Dent J 1993;43:431-9. Am J Clin Nutr 2005;82(5):1017-1023. J Health Popul.Nutr. Godfrey JC, Conant Sloane B, Smith DS, et al. Sorensen JA, Andersen O. View abstract. 2020;59(5):1815-1827. Taneja, S., Bhandari, N., Rongsen-Chandola, T., Mahalanabis, D., Fontaine, O., and Bhan, M. K. Effect of zinc supplementation on morbidity and growth in hospital-born, low-birth-weight infants. Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy. Heyneman CA. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Learn how mineral deficiency occurs and how its treated. View abstract. View abstract. 1985;19(1):97-100. Treatment of Wilson's disease with zinc: XI. Does hair zinc predict amphetamine improvement of ADD/hyperactivity? 2021;10(2):127-139. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. J Microbiol Immunol Infect. View abstract. 2013 Oct;67(10):1056-9. Lu, H., Cai, L., Mu, L. N., Lu, Q. Y., Zhao, J., Cui, Y., Sul, J. H., Zhou, X. F., Ding, B. G., Elashoff, R. M., Marshall, J., Yu, S. Z., Jiang, Q. W., and Zhang, Z. F. Dietary mineral and trace element intake and squamous cell carcinoma of the esophagus in a Chinese population. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Fleet JC, Turnbull AJ, Bourcier M, Wood RJ. This article looks at its benefits, potential risks, sources, and the research behind its health effects. View abstract. Sinha B, Dudeja N, Chowdhury R, et al. J Neuroophthalmol 2001;21:32-3. Zhou JR, Erdman JW Jr. Phytic acid in health and disease. J Assoc.Physicians India 1998;46(11):939-942. Dietary zinc intake and incident chronic kidney disease. Hill, G. M., Brewer, G. J., Juni, J. E., Prasad, A. S., and Dick, R. D. Treatment of Wilson's disease with zinc. BMJ 2002;324:1358. Hebel SK, ed. View abstract. Zinc tolerance test in uremia: effect of calcitriol supplementation. Int J Epidemiol. View abstract. Trace Elements in Human Health and Disease. Jafari A, Noormohammadi Z, Askari M, Daneshzad E. Zinc supplementation and immune factors in adults: a systematic review and meta-analysis of randomized clinical trials. Zinc intake and risk of prostate cancer: Case-control study and meta-analysis. Nutrients 2021;13(6):1814. Alcala-Santaella, R., Castellanos, D., Velo, J. L., and Gonzalez, Lara, V. Zinc acexamate in treatment of duocenal ulcer. Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Li Z, Li B, Song X, Zhang D. Dietary zinc and iron intake and risk of depression: A meta-analysis. View abstract. BMJ 2001;322:1567. 2016;124(1):28-33. Effects of iron, tin, and copper on zinc absorption in humans. JAMA 2005;294:3101-7. View abstract. View abstract. View abstract. Arch Ophthalmol 2001;119:1439-52. View abstract. Fine, D. H., Furgang, D., Sinatra, K., Charles, C., McGuire, A., and Kumar, L. D. In vivo antimicrobial effectiveness of an essential oil-containing mouth rinse 12 h after a single use and 14 days' use. Ead RD. Zeng, L. and Zhang, L. Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. View abstract. FREE delivery Mon, Feb 13 on $25 of items shipped by Amazon. Nig.Q.J Hosp.Med. Fatal deterioration of Wilson's disease after institution of oral zinc therapy. Chilvers DC, Jones MM, Selby PL, et al. Am J Clin Nutr 2003;78:279-83.. View abstract. Endocr Metab Immune Disord Drug Targets. Patel, A. Lin, Y. S., Lin, L. C., and Lin, S. W. Effects of zinc supplementation on the survival of patients who received concomitant chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow-up of a double-blind randomized study with subgroup analysis. Leonard MB, Zemel BS, Kawchak DA, et al. Association of zinc and antioxidant nutrients with age-related maculopathy. Eur.J Clin Nutr 2009;63(1):65-70. Zinc supplementation and the effects on pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Khattar, J. Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds. View abstract. Solomons NW, Jacob RA. Am J Clin Nutr 1997;65:1803-9. Cochrane Database Syst Rev. Humphreys, E. H., Smith, N. A., Azman, H., McLeod, D., and Rutherford, G. W. Prevention of diarrhoea in children with HIV infection or exposure to maternal HIV infection. Oral Surg Oral Med Oral Pathol 1982;53:469-72. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. View abstract. Clin Nutr. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. Z. Roy SK, Tomkins AM, Akramuzzaman SM, et al. View abstract. Br.J.Dermatol. View abstract. Cochrane Database Syst Rev. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Kelly P, Musonda R, Kafwembe E, et al. 2003;10(5):324-329. If you suspect that you may have a deficiency, a doctor can test your blood levels to determine if a supplement could be beneficial. Compend Contin Educ Dent 1998;19:4-15. 2021;25(1):363. View abstract. Serum and hair zinc levels in epileptic children taking valproic acid. 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