Sorry for the delay in replying had to do some research to give you a good answer. In FL resistance is bad, and we split our time between FL & NJ. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. ivermectin, selamectin)? I found some good information on the Cyphenothrin in Parastar Plus in this article. We gave her the first dose in late February and there were no adverse side effects for Sugar. As with any topical, of course keep an eye out for skin irritation. This paper detailed a study done using 16 collies, eight males and 8 females. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. Freckles my Aussie/Pyr is such a great dog. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. You can even scatter some on your dogs bed. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. It has the same active ingredients as Seresto (plus one), so a bit stronger. (Basically, I did the boring work to bring you the helpful information.). Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. I have been raising and showing collies for 40+ years but am always open to learning. Hi Vicki, Thank you so much for writing this article!!! With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . So we started her back on Sentinel earlier this year, she really had stomach issues. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at We recently switched our dogs to a new product called Simparica Trio. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. (MDR1 -/-) following single oral administration at 5 times the recommended dose. , Thanks for the reply! thanks for your research. Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. Thanks for your efforts to help! Congratulations on the new kitten. (More on those later.). No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. And each monthly chewable tablet has a palatable liver . Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. (There are other places, but none more affordable that Ive found.) I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. We can eat it. Have you had any issues with Seresto? Like Nexgard, Simparica needs to . Somewhere I read that its good for 4 kinds. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). It provides 100% protection from heartworm disease. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. I have a one year old Aussie mix. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. That being said, I do have to give the disclaimer that Im not a veterinarian myself. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Before I got them home, they went into comas. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. Appreciated!!! If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Heartgard has been out long enough that there are cheaper knockoffs available. MDR1 FAQs. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Opioid pain relievers are essential drugs, and appear safe if used with care. Natural Chemistry claims to kill on contact and to be safe for puppies. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Tap to zoom. ? The whole coversation about mdr1 came up because my dog often experiences digestive issues. Thats what Im doing for my most recent Collie. Just as another concern, I had two cats die from Advantage Multi. It probably is the safest as it is aimed only at preventing heartworm. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Is this true? Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. 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